It’s Not Necessarily All about the Delivery in Huntington’s Disease
نویسندگان
چکیده
Existing models of Huntington's disease posit that deficits in BDNF delivery to the striatum contribute to atrophy and motor impairment. In this issue of Neuron, Plotkin et al. (2014) show that BDNF delivery is normal but downstream signaling via TrkB and p75 is impaired, leading to corticostriatal synaptic dysfunction.
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عنوان ژورنال:
- Neuron
دوره 83 شماره
صفحات -
تاریخ انتشار 2014